Written by Gabriele Dennert and the CAM-Cancer Consortium.
Updated July 26, 2013


What is it?


Lycopene forms the red pigment in fruit such as tomatoes, apricots, guavas, pink grapefruits, rosehips or watermelons 1 and is involved in the photosynthesis of plants, algae and other organisms that actively generate energy through photosynthesis. It is chemically a carotenoid, but is not an essential food ingredient for humans.

In Western countries, tomatoes and tomato products have been found to be the major nutritional source of lycopene for humans.


Lycopene is a lipophilic, acyclic (C40H56) carotenoid with no provitamin-A activity, which means it is not metabolized to vitamin A in the body. It is insoluble in water and exists naturally in an all-trans isoform and several cis-isoforms.

Application and dosage

The level of intake optimal for human health has not been established. This summary concerns the supplemental intake of lycopene. Supporters of the supranutritional intake of lycopene often recommend adding between 15 and 40 mg to their daily diet. Lycopene is obtained from processed tomato products (juice), functional foods enriched with lycopene or as nutritional supplements. Nutritional supplements contain pure lycopene, extracted from either natural or synthetic sources, at doses of between 5 and 25mg per tablet or capsule.

Tomato juice or sauce contains about 9mg of lycopene per100g.2

Lycopene is intestinally absorbed. Some studies found that absorption is higher in the presence of dietary lipids, and from processed tomato products, than from raw tomatoes. (Overview in 1) Several studies have shown that the additional intake of lycopene (between 20 and 40mg/day) in the form of tomato products or nutritional supplements increased the plasma lycopene level. (Overview in 3) One pharmacokinetic study found peak plasma levels of lycopene at 0.5–6 hours after oral ingestion and an elimination half-life of between two and five days. Lycopene and its metabolites were transported to the skin in this study, where it remained detectable for up to 42 days.4 Lycopene seems to be eliminated and excreted via the bile duct and the kidneys.


Lycopene was named after the fruit from which it was first isolated, namely the tomato (Lycopersicum esculentum), by the chemist C.A. Schunck in 1903.5

Lycopene supplements or lycopene-enriched functional foods are marketed by various companies.

Claims of efficacy

Following epidemiologic studies, which have linked higher intake of lycopene to a reduced risk of developing prostate cancer as well as cardiovascular diseases 6 lycopene has been promoted for cancer prevention and general health improvement. It has been suggested that it exhibits antioxidant activities, inhibits cell proliferation and inducts apoptosis.

To date, there is contradictory epidemiologic evidence regarding the association of lycopene intake and cancer risk: studies of lung cancer 7 or ovarian cancer 8 found a reduced risk associated with higher lycopene levels or intake, but studies of colon cancer 9 or breast cancer 10 found no protective association regarding increased lycopene intake.

Alleged indication(s)

Lycopene has been proposed as being active in the prevention of cancer, in particular prostate cancer, and other disease, e.g. cardiovascular diseases. As well as exhibiting beneficial effects in prostate cancer and lung cancer patients, it has been suggested as helpful in protecting against the adverse effects of chemotherapy.38

Mechanism(s) of action

Several biological mechanisms of lycopene and its metabolites have been described and suggested as linked to cancer development and prevention in humans.11 However, the metabolism and biological effects of lycopene are still not fully understood and, to date, studies have yielded discrepant results.

Some studies with healthy volunteers found that the intake of additional lycopene decreased the level of biomarkers of oxidative stress, while other investigations showed no effect.3 In one randomized clinical trial (RCT) involving male African American urology patients, no antioxidant effect of lycopene supplementation prior to prostate biopsy (30 mg/day for 21 days) could be seen.12

Another investigation with healthy volunteers suggested that the intake of lycopene (30 mg/day) increased serum insulin-like growth factor (ILGF)-binding protein-1 and -2 concentrations 13, which might lower ILGF-levels and prevent its possible cancer-promoting effects. Lycopene has also been linked to androgen metabolism and has been found to lower testosterone levels in mice mediated by genetic variations of enzymes of the carotenoid-metabolism.14

Some animal and in-vitro studies found a protective effect of lycopene against chemotherapy-induced toxicities, e.g. nephron- and cardiotoxicity of cisplatin or Adriamycin, while others did not. (15, overview in 16)

In an in-vitro model, lycopene at a physiological level did not show as having a significant effect on the proliferation of normal and malignant cells.17

Prevalence of use

In a US sample of prostate cancer patients, 11% of men used lycopene or tomato products.18

Legal issues

For functional foods and nutritional supplements, EU and national regulations apply.

Cost(s) and expenditures

Thirty tablets (15–25 mg lycopene each) – one-month’s supply – are available in Europe for around €25 via internet sellers.

Citation Gabriele Dennert, CAM-Cancer Consortium. Lycopene [online document]. http://ws.cam-cancer.org/The-Summaries/Herbal-products/Lycopene. July 26, 2013.


  1. Diener RM, Christian MS. Lycopene Overview: What It Is and What It Does. In: VR Preedy, RR Watson (Eds.): Lycopene : nutritional, medicinal and therapeutic properties. Enfield: Science Publishers. 2008; 3-16.
  2. Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res. 2007; 55(3): 207–16. doi:10.1016/j.phrs.2007.01.012.
  3. Basu A, Imrhan V. Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Eur J Clin Nutr. 2007; 61: 295-303.
  4. Ross AB, Vuong LT, Ruckle J, Synal HA, Schulze-König T, Wertz K, Rümbeli R, Liberman RG, Skipper PL, Tannenbaum SR, Bourgeois A, Guy PA, Enslen M, Nielsen ILF, Kochhar S, Richelle M, Fay LB, Williamson G. Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study. Am J Clin Nutr. 2011; 93:1263–73.
  5. Schunck CA. The Xanthophyll Group of Yellow Colouring Matters. Proc R Soc Lond. 1903; 72(477-486): 165-176. doi: 10.1098/rspl.1903.0035.
  6. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst. 1999; 91: 317-331.
  7. Michaud DS, Feskanich D, Rimm EB, Rimm EB, Colditz GA, Speizer FE, Willett WC, Giovanucci E. Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. Am J Clin Nutr 2000; 72: 990-997.
  8. Cramer DW, Kuper H, Harlow BL, Titus-Ernstoff L. Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women.Int J Cancer 2001; 94: 128-134.
  9. Slattery ML, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD. Carotenoids and colon cancer. Am J Clin Nutr 2000; 71: 575-582.
  10. Sesso HD, Buring JE, Zhang SM, Norkus EP, Gaziano JM. Dietary and plasma lycopene and the risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 1074-1081.
  11. Mein JR, Lian F, Wang X-D. Biological activity of lycopene metabolites: implications for cancer prevention. Nutr Rev. 2008; 66(12): 667–683. doi:10.1111/j.1753-4887.2008.00120.x
  12. van Breemen,RB, Sharifi R, Viana M, Pajkovic N, Zhu D, Yuan L, Yang Y, Bowen PE, Stacewicz-Sapuntzakid M. Antioxidant effects of lycopene in African American Men with Prostate Cancer or Benign Prostate Hyperplasia: A Randomized, Controlled Trial. Cancer Prev Res. 2001; 4: 711-718.
  13. Vrieling A, Voskuil DW, Bonfrer JM, Korse CM, van Doorn J, Cats A, Depla AC, Timmer R, Witteman BJ, van Leewen FE, van´t Veer LJ, Rookus MA, Kampman E. Lycopene supplementation elevates circulating insulin-like growth factor-binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am J Clin Nutr. 2007; 86: 1456-1462.
  14. Ford NA, Engelmann Moran N, Smith JW, Clinton SK, Erdman JW (Jr.). An interaction between carotene-15,15´-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone. Internatl J Cancer. 2012; 131: E143-E148.
  15. Anjos Ferreira AL, Russell RM, Rocha N, Placido Ladeira MS, Favero Salvadori DM, Oliveira Nascimento MC, Matsui M, Carvalho FA, Tang G, Matsubara LS, Matsubara BB. Effect of lycopene on doxorubicin-induced cardiotoxicity: an echocardiographic, histological and morphometrical assessment. Basic Clin Pharmacol Toxicol. 2007;101:16-24.
  16. Sahin K, Sahin N, Kucuk O. Lycopene and Chemotherapy Toxicity. Nutr Cancer. 2010; 62: 988-995.
  17. Burgess LC, Rice E, Fischer T, Seeking JR, Burgess TP, Sticka SJ, Klatt K. Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range. Toxicol in Vitro. 2008; 22: 1297-1300.
  18. Boon H, Westlake K, Stewart M, Gray R, Fleshner N, Gavin A, Brown JB, Goel V. Use of Complementary/Alternative Medicine by Men Diagnosed With Prostate Cancer: Prevalence and Characteristics. Urology. 2003; 62: 849-853.
  19. Ilic D, Forbes KM, Hassed C. Lycopene for the prevention of prostate cancer. Cochrane Database of Systematic Reviews 2011, Issue 11. Art. No.: CD008007. DOI: 0.1002/14651858.CD008007.pub2.
  20. Mohanty N, Saxena S, Singh U, Goyal N, Arora R. Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia. UrologicOncology: Seminars and Original Investigations 2005;23:383–385.
  21. Bunker C, McDonald A, Evans R, de la Rosa N, Boumosleh J, Patrick A. A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. Nutrition and Cancer 2007; 57:130–137.
  22. Schwarz S, Obermuller-Jevic U, Hellmis E, Koch W, Jacobi G, Biesalski H. Lycopene inhibits disease progression in patients with Benign Prostate Hyperplasia. The Journal of Nutrition and Disease 2008; 138: 49–53.
  23. Haseen F, Cantwell MM, O´Sullivan JM, Murray LJ. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic Dis. 2009; 12: 325-332.
  24. Ansari MS, Gupta NP. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2003; 92: 375-378.
  25. Kucuk O, Sarkar FH, Sark W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS, Crissman JD, Pontes EJ, Wood DP. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidem Biomarker Prev. 2001; 10: 861-868.
  26. Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, Sharifi R, Christoph K. Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. Nutr Cancer. 2003; 47: 40-47.
  27. Ansari MS, Gupta NP. Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol. 2004; 22: 415-20.
  28. Barber NJ, Zhang X, Zhu G, Pramanik R, Barber JA, Martin FL, Morris JD, Muir GH. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer Prostatic Dis. 2006; 9:407-13.
  29. Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, Ashton D, Bowen PE. Oxidative DNA damage in ate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst. 2001; 93:1872-1879.
  30. Jatoi A, Burch P, Hillman D, Vanyo JM, Dakhil S, Nikcevich D, Rowland K, Morton R, Flynn PJ, Young C, Tan W; North Central Cancer Treatment Group. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology. 2007; 69: 289-294.
  31. Clark PE, Hall MC, Borden LS Jr, Miller AA, Hu JJ, Lee WR, Stindt D, D'Agostino R Jr, Lovato J, Harmon M, Torti FM. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology. 2006; 67: 1257-1261.
  32. Shao A, Hatchcock JN. Risk Assessment of Lycopene. In: VR Preedy, RR Watson (Eds.): Lycopene : nutritional, medicinal and therapeutic properties. Enfield: Science Publishers. 2008; 83-104.
  33. Banerjee S, Jeyaseelan S, Guleria R.: Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J Obstet Gynaecol Res. 2009 Jun;35(3):477-482.
  34. Veeramachaneni S, Ausman LM, Choi SW, Russell RM, Wang XD. High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats. J Nutr. 2008;138:1329-1335.
  35. Sunaga K, Ohkawa K, Nakamura K, Ohkubo A, Harada S, Tsuda T. Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol Pharm Bull. 2012; 35:329-334.
  36. Feifer AH, Fleshner NE, Klotz L. Analytical accuracy and reliability of commonly used nutritional supplements in prostate disease. J Urol. 2002;168:150-154.
  37. Linus Pauling Institute. Carotenoids. Alpha-Carotene, Beta-Carotene, Beta-Cryptoxanthin, Lycopene, Lutein, and Zeaxanthin. http://lpi.oregonstate.edu/infocenter/phytochemicals/carotenoids/ [last access 15/11/2012]
  38. Sahin K, Sahin N, Kucuk O. Lycepene and chemotherapy toxicity. Nutr Cancer 2010; 62(7): 988-95.