Written by Helen Seers, Katja Boehm and the CAM-Cancer Consortium.
Updated December 5, 2015


Abstract and key points

  • Aromatherapy involves the controlled use of aromatic essential plant oils.
  • Weak evidence is available to indicate that aromatherapy can improve overall quality of life; may be of potential benefit for physical problems (pain or fatigue), psychological problems (anxiety, depression, sleep).
  • There is no strong evidence for long-term aromatherapy effects (after several weeks).
  • Aromatherapy is generally safe; the greatest risks involve the consumption of larger amounts of essential oil or the application of essential oils to the skin, which may cause allergic contact dermatitis.

Aromatherapy, also called essential or volatile oil therapy, entails the controlled use of essential oils that have been extracted from a variety of plant sources. Therapy is usually given via massage, inhalation or a foot- or full-body bath.

Claims of benefits for cancer patients include reduced anxiety levels and relief of emotional stress, pain, muscular tension and fatigue. Claims for the effect of certain oils range from ‘restoring harmony to the energy’ of the body, altering mood and improving overall health, to more specific claims such as having anticonvulsive and spasmolytic properties.

The latest systematic review (2009) on the topic, which included six randomised and non-randomised controlled trials, concluded that although there is no long-lasting effect of aromatherapy massage, short-term improvements can be reported for general wellbeing, anxiety and depression up to eight weeks after treatment. Evidence from an additional 14 randomised and non-randomised clinical trials, of varying methodological quality is contradictory; more consistent research is needed to assess the long-term effects of aromatherapy for people with cancer.

Although essential oils have generally shown minimal adverse effects, when used in appropriate dilutions, allergic reactions can occur with all oils. Repeated topical administration of lavender and tea tree oil has been associated with reversible prepubertal gynecomastia, consequently there may be issues for cancer patients with oestrogen-dependant tumours.

Read about the regulation, supervision and reimbursement of herbal medicine at NAFKAMs website CAM Regulation.

Citation Helen Seers, Katja Boehm, CAM-Cancer Consortium. Aromatherapy [online document]. http://ws.cam-cancer.org/The-Summaries/Herbal-products/Aromatherapy. December 5, 2015.


  1. Tisserand R, Balacs T. Essential oil safety. Edinburgh: Churchill Livingstone, 1995.
  2. Tisserand R. Essential oils as psychotherapeutic agents. In: Van Toller S, Dodd GH, eds. Perfumery: The Psychology and Biology of Fragrance. New York, NY: Chapman and Hall, 1988, pp 167-80.
  3. Gattefossé RM. Gattefossé's Aromatherapy. Edited by R Tisserand, Translated by L Davies. Saffron Waldon: The CW Daniel Company, 1993.
  4. Ljunggren B. Severe phototoxic burn following celery ingestion. Arch Dermatol 1990;126:1334-6.
  5. Wilkinson S, Barnes K, Storey L. Massage for symptom relief in patients with cancer: systematic review. J Adv Nurs 2008;63:430-9.
  6. Perry N, Perry E. Aromatherapy in the management of psychiatric disorders: clinical and neuropharmacological perspectives. CNS Drugs 2006;20: 257-80.
  7. Hudson R. The value of lavender for the rest and activity in the elderly patient. Complement Ther Med. 1996;4:52–7.
  8. Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther 2012;11:187-203
  9. Yim VW, Ng AK, Tsang HW, Leung AY. A review on the effects of aromatherapy for patients with depressive symptoms. J Altern Complement Med 2009;15:187-95.
  10. Chang SY. Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer. J Korean Acad Nurs 2008;38:493-502.
  11. Ndao DH, Ladas EJ, Cheng B, Sands SA, Snyder KT, Garvin JH, Kelly KM. Inhalation aromatherapy in children and adolescents undergoing stem cell infusion: results of a placebo-controlled double-blind trial. Psychooncology 2012; 21: 247–54.
  12. Lai TK, Cheung MC, Lo CK, Ng KL, Fung YH, Tong M, Yau CC. Effectiveness of aroma massage on advanced cancer patients with constipation: a pilot study. Complement Ther Clin Pract 2011;17:37-43.
  13. Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D, Maddocks-Jennings W, Wilkinson JM, et al. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. European Journal of Oncology Nursing 2009 ;13:87-93.
  14. Stringer J, Swindell R, Dennis M, Stringer J, Swindell R, Dennis M. Massage in patients undergoing intensive chemotherapy reduces serum cortisol and prolactin. Psycho-Oncology 2008;17:1024-31.
  15. Serfaty M, Wilkinson S, Freeman C, Mannix K, King M. The ToT Study: Helping with Touch or Talk (ToT): a pilot randomised controlled trial to examine the clinical effectiveness of aromatherapy massage versus cognitive behaviour therapy for emotional distress in patients in cancer/palliative care. Psychooncology 2012;21:563-9.
  16. Potter P, Eisenberg S, Cain KC, Berry DL. Orange interventions for symptoms associated with dimethyl sulfoxide during stem cell reinfusions: a feasibility study. Cancer Nurs 2011;34:361-8.
  17. Louis M, Kowalski SD. Use of aromatherapy with hospice patients to decrease pain, anxiety, and depression and to promote an increased sense of well-being. Am J Hosp Palliat Care 2002;19:381-6.
  18. Kang HY, Na SS, Kim YK. Effects of oral care with essential oil on improvement in oral health status of hospice patients. J Korean Acad Nurs 2010;40:473-81.
  19. Graham PH, Browne L, Cox H, et al. Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol 2003;21: 2372-6.
  20. Anonymous. Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil. International Journal of Toxicology. 2001;20 Suppl 2:31-9.
  21. Clark SM, Wilkinson SM. Phototoxic contact dermatitis from 5-methoxypsoralen in aromatherapy oil. Contact Dermatitis 1998;38: 289–90.
  22. Henley DV, Lipson N, Korach KS, et al. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007; 356:479-85.
  23. Hongratanaworakit T, Buchbauer G. Human behavioral and physiological reactions to inhalation of sweet orange oil. Acta Hort 2005;679:75-81.
  24. Holmes C, Ballard C. Aromatherapy in dementia. Advances in Psychiatric Treatment 2004; 10: 296–300.
  25. Ernst E, Pittler MH, Wider B, Boddy K. The Oxford Handbook of Complementary Medicine. Oxford: Oxford University Press, 2008.
  26. University of Maryland Medical Center. Lavender [online document], accessed 5th December 2015.
  27. Khiewkhern S, Promthet S, Sukraprasert A, Eunhpinitpong W, Bradshaw P. Effectiveness of aromatherapy with light thai massage for cellular immunity improvement in colorectal cancer patients receiving chemotherapy. Asian Pac J Cancer Prev 2013;14(6):3903-7.
  28. Lua PL, Salihah N, Mazlan N. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement Ther Med 2015;23:396-404.
  29. Tang WR, Chen WJ, Yu CT, Chang YC, Chen CM, Wang CH, Yang SH. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med 2014;22:581-91.
  30. Ovayolu O, Seviğ U, Ovayolu N, Sevinç A. The effect of aromatherapy and massage administered in different ways to women with breast cancer on their symptoms and quality of life. Int J Nurs Pract 2014;20:408-17.
  31. Cancer Research UK. Aromatherapy, accessed 12th August 2015.
  32. Alliance of International Aromatherapists. A brief history of aromatherapists [web document], accessed 5th  December 2015.