Written by Markus Horneber, Elke Wolf and the CAM-Cancer Consortium.
Updated February 28, 2017

Propagermanium

Does it work ?

Evidence concerning the efficacy of propagermanium comes from two clinical trials 17, one review including seven case series 21, a case series 16 and one case report 22.

The clinical trials were reported with fragmentary data and a few sentences in a conference report 17. One of them was a controlled study comparing two concentrations of propagermanium in 35 lung cancer patients. Higher survival rates were alleged in patients who received a not further specified dose above 20 mg/kg/day. The other study was referred to as a placebo controlled trial in patients with lung cancer during chemotherapy. Higher response and survival rates after 3 months were alleged in the propagermanium group. The sparse data given in the conference report do not allow any serious judgement and a more complete publication was not traceable.

A 1987 review summarized results of seven case series in which propagermanium was given during chemotherapy or radiotherapy. According to the authors, the clinical courses suggested ”antitumour efficacy” and “a reduction of tumour-associated pain in several patients” 21.

A further case series describes the outcome of 10 patients with multiple myeloma being treated with daily doses of 10 to 40 mg propagermanium. Authors refer complete or partial responses in four patients as measured by decreases or normalisations of paraprotein levels. In the two complete responders bone marrow biopsy showed also a reduction of plasma cells 16. Time points of measuring were not reported and in three of the patients the interval to former chemotherapy treatment was rather short. Therefore it is debateable whether the effect was truly attributable to propagermanium.

A well documented complete remission of a rare form of lung cancer (spindle cell carcinoma) refractory to radiation therapy and various chemotherapies in a female 47-year-old patient was published in 2000. After 5 months of self-medication with propagermanium, the patient achieved complete remission, which at the time of the report had lasted more than four years 22.

Citation Markus Horneber, Elke Wolf, CAM-Cancer Consortium. Propagermanium [online document]. http://ws.cam-cancer.org/The-Summaries/Dietary-approaches/Propagermanium. February 28, 2017.

References

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