Written by Luc Geeraert and the CAM-Cancer Consortium.
Updated June 29, 2017

Insulin potentiation therapy

Is it safe?

Adverse events

The main risk of insulin administration is hypoglycaemia or low blood glucose levels. In a small prospective, randomized clinical trial of IPT 5, toxicities recorded with methothrexate alone, at a lower dose (2.5 mg/m2) than the conventional one, were considered non-relevant (WHO grades 1 or 2). Toxicities in the methotrexate/insulin treated group (IPT) were even lower (only WHO grade 1).

Contraindications

The use of certain types of insulin is contraindicated in people having allergic reactions to them 21. IPT during pregnancy may harm the foetus.

Interactions

Low blood sugar caused by IPT may have more severe effects in diabetics treated with pills to lower the blood sugar 21. Beta-blockers can mask the symptoms of low blood sugar, making it harder to detect low blood sugar before dangerously low levels are being reached. Sulfa antibiotics and excessive amounts of alcohol can make the blood sugar levels go even lower.

Warnings

The use of chemotherapeutic drugs at only 10%-25% of the recommended dose is a concern 21. There is no evidence that such low doses of chemotherapy in combination with insulin can produce the same anticancer effect as the recommended doses. Moreover, the use of lower doses of chemotherapeutic drugs may promote drug resistance.

It is important to note that insulin may actually promote tumour growth 22,23. Multiple and complex mechanisms are potentially responsible for this tumour growth promoting effect. Most cancer cells express receptors for insulin and the insulin-like growth factor (IGF), via which insulin can directly stimulate cell division, proliferation, and metastasis. Apart from this direct effect, insulin increases the levels of circulating IGF-I, which has more potent effects on promotion of cell division and against apoptosis than insulin itself. It is still unclear how these effects translate into the clinic, but in some cancers (e.g., breast and colon cancer) data indicating a possible link between high insulin levels and poor outcomes in cancer are accumulating 24,25.

Citation Luc Geeraert, CAM-Cancer Consortium. Insulin potentiation therapy [online document]. http://ws.cam-cancer.org/The-Summaries/Dietary-approaches/Insulin-potentiation-therapy. June 29, 2017.

References

  1. Ayre SG, Perez Garcia y Bellon D, Perez Garcia D Jr. Insulin potentiation therapy: a new concept in the management of chronic degenerative disease. Med. Hypotheses. 1986 Jun;20(2):199-210.
  2. Joshi SR, Parikh RM, Das AK. Insulin--history, biochemistry, physiology and pharmacology. J. Assoc. Physicians India. 2007 Jul;55 Suppl:19-25.
  3. Ayre SG, Garcia y Bellon DP, Garcia DP Jr. Insulin, chemotherapy, and the mechanisms of malignancy: the design and the demise of cancer. Med. Hypotheses. 2000 Oct;55(4):330-334.
  4. Damyanov C, Gerasimova D, Maslev I, Gavrilov V. Low-dose chemotherapy with insulin (insulin potentiation therapy) in combination with hormone therapy for treatment of castration-resistant prostate cancer. ISRN Urol. 2012;2012:140182.
  5. Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. Insulin-induced enhancement of antitumoral response to methotrexate in breast cancer patients. Cancer Chemother. Pharmacol. 2004 Mar;53(3):220-224.
  6. Murray I. Paulesco and the isolation of insulin. J. Hist. Med. Allied Sci. 1971 Apr;26(2):150-157.
  7. Bliss M. The history of insulin. Diabetes Care. 1993 Dec;16 Suppl 3:4-7.
  8. De Meyts P. Insulin and its receptor: structure, function and evolution. Bioessays. 2004 Dec;26(12):1351-1362.
  9. Sandow J. Growth effects of insulin and insulin analogues. Arch. Physiol. Biochem. 2009 May;115(2):72-85.
  10. Straus DS. Growth-stimulatory actions of insulin in vitro and in vivo. Endocr. Rev. 1984 Spring;5(2):356-369.
  11. Arizona Center for Advanced Medicine. Frequently Asked Questions About IPTLD [online document]. Available from http://arizonaadvancedmedicine.com/therapies/IPT_therapy.html, last accessed 29th June 2017.
  12. Baratz R, Why you should stay away from insulin potentiation therapy.Quackwatch.org [Internet]. August 2013. Available from http://www.quackwatch.org/01QuackeryRelatedTopics/Cancer/ipt.html, last accessed 29th June 2017.
  13. Damyanov C, Radoslavova M, Gavrilov V, Stoeva D. Low dose chemotherapy in combination with insulin for the treatment of advanced metastatic tumors. Preliminary experience. J. BUON. 2009 14(4):711–715.
  14. Ayre SG, Perez Garcia y Bellon D, Perez Garcia D Jr. Neoadjuvant low-dose chemotherapy with insulin in breast carcinomas. Eur. J. Cancer. 1990;26(11-12):1262-1263.
  15. Peacock JL, Gorschboth CM, Norton JA. Impact of insulin on doxorubicin-induced rat host toxicity and tumor regression. Cancer Res. 1987 Aug 15;47(16):4318-4322.
  16. Oster JB, Creasey WA. Enhancement of cellular uptake of ellipticine by insulin preincubation. Eur. J. Cancer Clin. Oncol. 1981 Oct;17(10):1097-1103.
  17. Alabaster O, Vonderhaar BK, Shafie SM. Metabolic modification by insulin enhances methotrexate cytotoxicity in MCF-7 human breast cancer cells. Eur. J. Cancer Clin. Oncol. 1981 Nov;17(11):1223-1228.
  18. Jiao SC, Huang J, Sun Y, Lu SX. [The effect of insulin on chemotherapeutic drug sensitivity in human esophageal and lung cancer cells]. [Article in Chinese]. Zhonghua Yi Xue Za Zhi. 2003 Feb 10;83(3):195-197.
  19. Zou K, Ju JH, Xie H. Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells. Acta Pharmacol. Sin. 2007 May;28(5):721-730.
  20. Kern DH, Chien FW, Morton DL. Selective effects of insulin and hydrocortisone on colony formation and chemosensitivity of human tumors in soft agar. Int. J. Cancer. 1984 Jun 15;33(6):807-812.
  21. Memorial Sloan Kettering Cancer Center. Insulin Potentiation Therapy [online document]. Available from: https://www.mskcc.org/cancer-care/integrative-medicine/herbs/insulin-potentiation-therapy#field-herb-drug-interactions, last accessed 29th June 2017 .
  22. Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. CA Cancer J. Clin. 2010 July-August;60(4):207-221.
  23. Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Endocr. Relat. Cancer. 2009 December;16(4):1103-1123.
  24. Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Madarnas Y, Hartwick W, Hoffman B, Hood N. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J. Clin. Oncol. 2002 January 1;20(1):42-51.
  25. Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL, Fuchs CS. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J. Clin. Oncol. 2009 Jan 10;27(2):176-185.